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HK2 expression regulates the levels of proinflammatory cytokines (IL-6, IL-8) in OA (77)
Additionally, GLP-1RAs ameliorate DPN through various mechanisms, including the inhibition of inflammation, oxidative stress, and extracellular matrix remodeling, while simultaneously improving neural structure, function, and energy metabolism [11, 12, 30, 79,80,81,82,83,84,85,86]
Intracellularly, GSH is maintained in its thiol-reduced form by NADPH-dependent enzymes (glutathione disulfide bond (GSSG) reductase)
Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
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Biochem Pharmacol 83, 170183, doi: 10.1016/j.bcp.2011.09.024 (2012)
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