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When intracellular B12 is insufficient, methylmalonic acid (MMA) and homocysteine levels rise

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Therapy with antagonists also avoids a clinical flare in disease caused by a transient release of LH and sex steroids, which occurs in various patients during agonist administration

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Manufacturers recommend stopping these medications before attempting pregnancy because fetal exposure during early organ development poses unknown risks

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In contrast to folate deficiency, the small folate cycle can run almost as normal

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P., Dudek, J., Merlino, G

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