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This synergy may result from GHK-Cu stimulating glycosaminoglycan production and promoting collagen synthesis, while HA may reduce collagen degradation by scavenging reactive oxygen species and inhibiting matrix metalloproteinases

Among these, 183 trials were registered on ClinicalTrial.gov, 56 were identified from other trial registries such as the ICTRP and Australian New Zealand Clinical Trials Registry (ANZCTR), and 23 were standalone publications not linked to any available registration

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doi: 10.1111/1440-1681.13906 205 PeterKNobertBHannsMartinLWolfgangM