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It acts by mimicking the endogenous hormone ghrelin and binding to the growth hormone secretagogue receptor type 1a (GHS-R1a) in the anterior pituitary gland

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10.2217/thy.11.12. Estensen RD, Levy M, Klopp SJ, et al

The earliest evidence came from one of the earliest forms of evidence came from a guy called Wilder Penfield