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Notably, citrulline supplementation restores fibroblast activation under arginine-deprived conditions, whereas ornithine and glutamine provide essential precursors for polyamine biosynthesis in fibroblasts [50]

Notably, Nrf2 plays a dual protective role by both repressing neuroinflammatory signaling and promoting the transcription of antioxidant genes, establishing it as a compelling therapeutic target in neurodegenerative disorders [182, 183]

The rate-limiting step in VLDL assembly

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