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Even if the solution appears clear, bacterial contamination that is invisible to the eye can develop after 28 days

Additional information DISCLOSURE/CONFLICT OF INTEREST Michael Berk declares that over the past three years, he has received compensation from Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Norvatis, Mayne Pharma and Servier

Clinical evidence from hand OA studies reveals significant alterations in gut microbiome-derived tryptophan metabolites: serum levels of 5-hydroxyindoleacetic acid (5-HIAA) and 5-hydroxytryptophan (5-HTP) are elevated, whereas 3-HAA is reduced in symptomatic patients (Wei et al., 2023)

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