Back then, the more specific peptides that most of us were intrigued with were the GHRHs and the GHRPs where you could regulate your own endogenous and physiologic release of growth hormone because we knew growth hormone has some influence on repair and restoration of function, things like that, and also a profound influence on the immune system
Therefore, the development of this vaccine in clinical trials could be more complicated than in in vivo experiment, given the diverse physiological functions of GPNMB in normal cells
The study was supported by the National Institutes of Health, the American Heart Association, the American Diabetes Association and the Juvenile Diabetes Research Foundation
Dose-specific weight loss outcomes for tirzepatide Source: SURMOUNT-1 trial (Jastreboff et al., NEJM 2022)
Unknown long-term effects: No human study has followed patients for more than 612 months