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We then isolated fetal islets immediately following a 90-min IGF-1 or CON in vivo infusion and exposed them to glucose or potassium chloride to measure in vitro insulin secretion (IGF-1, n = 6

Le Chatelier et al., 2013

Unlike earlier medications that act on one or two hormone receptors, Retatrutide targets three key metabolic pathways GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors to help regulate appetite, control energy balance, and support fat metabolism

Data Availability Statement Data are contained within the article.

We hypothesize several reasons for these different results