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Indications: resulting either from organic heart disease or from cardiac surgical procedures inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility Contraindications: Patients with idiopathic hypertrophic subaortic stenosis (IHSS) and in patients who have shown previous manifestations of hypersensitivity to dobutamine Patients with IHSS have an asymmetric septal hypertrophy resulting in a dynamic left ventricular outflow obstruction (LVOT)

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The cross-sectional area increased by about 8% in the ch-OSA group, compared with about 4% in the placebo group

Increased flux in TCA cycle in the mitochondria enhances production of reductive equivalents and flux of the electrons in the electron transport chain (ETC)

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