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Preclinical studies demonstrate its ability to enhance glucose utilization, inhibit hepatic gluconeogenesis, and increase insulin sensitivity via activation of the AMP-activated protein kinase (AMPK) pathway (31)

This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

Oral minoxidil varies by provider and pharmacy

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