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Research from the National Institutes of Health shows that skin laxity after weight loss occurs because of damage to collagen and elastin fibers which prevents skin retraction

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In over-accumulated WAT, fatty acid by-products, mainly diacylglycerol (DAG), are metabolized through -oxidation in the tricarboxylic acid (TCA) cycle, and under the DAG stimulation of PKC, the NADPH oxidase is directly activated to generate excess ROS [145]