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Thyrotropin-releasing hormone (TRH) is released by the hypothalamus, and it stimulates the anterior pituitarys thyrotropin cells to release thyroid-stimulating hormone (TSH)

This can lead to an overgrowth

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Tirzepatide has not been studied in pregnant or breastfeeding women, and animal studies suggest potential fetal harm

However, it can also be useful in combination with other triggers, such as hypoxia, because studying multiple triggers provides a more holistic understanding of the mechanisms driving ECD and allows for a more robust and representative model that mirrors the pathophysiological conditions observed in vivo [219]