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Core symptoms span intrusive memories, hyperarousal, avoidance and negative shifts in mood and cognition (Petakh et al., 2024), yet clinical presentation is highly heterogeneousshaped by trauma type and individual neurobiology (Huckins et al., 2020)

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Deficiencies in thiamine result in neurological, muscular, and cardiac symptoms, and can occur in as little as 18 days of total dietary depletion

Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment